New Research Reveals Link Between Aortic Arch Stiffness and Lung Function Decline in Aging Mice
Introduction
Our team recently published a research article in Pediatric Discovery:
“Age‐Dependent Correlation of Pulmonary Function Impairment and Aortic Arch Stiffness in Mice”
Ayman Isbatan, Samuel Lee, Ali Imran Sarwar, Yuxing Yuan, Sunny Chen, Maricela Castellon, Dan Marian, Richard Minshall, Jie Tian, Irena Levitan, Jiwang Chen.
Pediatric Discovery, 2025; doi: 10.1002/pdi3.2525
This study investigated cardiopulmonary aging in C57BL/6 mice and uncovered a significant age-related correlation between declining lung function and increased aortic arch stiffness. Using echocardiography and flexiVent lung function measurements, the researchers found that while body weight was the strongest predictor of pulmonary variability, aortic arch stiffness reliably tracked the progression of pulmonary decline in both sexes. These findings position aortic arch stiffness as a promising noninvasive biomarker for early cardiopulmonary aging.
https://onlinelibrary.wiley.com/doi/10.1002/pdi3.2525