Please note that both core-assisted and self-directed studies at the CVRC are contingent upon prior approval of a PI's Animal Use Protocol by the Institutional Animal Care and Use Committee (IACUC). All the services related to preclinical models, preclinical imaging are listed below. If some specific services are not available, we are willing to develop models/procedures upon clients’ request.

  1. Rodent left ventricular and right ventricular echocardiography using Vevo 2100
  2. Rodent carotid and aorta arch stiffness measurement using Vevo 2100
  3. Microbubble contrast enhanced ultrasound
  4. Coronary artery blood flow reserve measurement using Vevo 2100
  5. Left ventricular strain echo image analysis
  6. Mouse liver tumor size measurement using Vevo 2100
  7. Zebrafish echocardiography using Vevo2100
  8. LargoX-microCT imaging
  9. in vivo hemodynamics (RVSP, LVSP, PAP) using Millar and Trisonics systems
  10. CODA blood pressure monitoring system
  11. Morphometry; pulmonary vascular remodeling
  12. SCIREQ Flexivent to measure lung function
  13. Arterial blood gas (ABG) analysis
  14. Treadmill for rodent exercise models
  1. Myocardial infarction (MI) and reperfusion
  2. Trans Aortic Constriction (TAC) Pressure overload model
  3. Middle cerebral artery occlusion (MCAO) Ischemic stroke
  4. TTC staining for rodent brain and heart samples to show infarction area
  5. Pulmonary vascular and aortic arch permeability assay in mice
  6. Brain blood barrier function measurement
  7. Isolated perfused mouse lung model to measure permeability (Kfc) and pulmonary vasoconstriction
  8. Bariatric surgery in mice
  9. Mouse lung angiography/vascular casting
  10. Cecal ligation puncture model of sepsis
  11. Rodent models of cardiac arrest
  12. Spinal cord and dorsal root ganglia drug delivery in mice
  13. Reduced Uterine Perfusion Pressure (RUPP) Model in Mice
  14. Bone marrow transplant in mice
  15. Aorta arch and other artery/vessel isolation
  16. Subcutaneous osmatic Pump Implantation
  17. Tail vein and retroorbital injections
  1. Flexivent system for lung mechanics measurement
  2. Kfc measurement using iPL system
  3. Excess lung water (ELW) measurement
  4. Echo to scan lung edema
  5. Lung permeability assay using Evans blue dye-albumin
  6. Measure PO2 (ABG assays)
  7. Drug delivery to the lung (noninvasively)
  8. Measure pulmonary vascular resistance (slope of pressure vs flow)
  9. Measure pulmonary vasoconstriction under acute hypoxia or high K+
  1. Hypoxia-mediated PH in mice and rats
  2. Hypoxia + Sugen-mediated PH in mice and rats
  3. Monocrotaline-mediated PH in rats
  4. Pulmonary artery banding (PAB) in mice
  5. Parasite induced PH
  6. RV echocardiography
  7. RV catheterization to measure RVSP and PAP in mice and rats
  8. RVH [RV/(LV+S)] measurement
  9. Pulmonary vessel casting and quantification
  10. Pulmonary artery wall thickness measurement
  11. PASMC, PAEC isolation from mice and rats